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Can Dogs Take Human Ondansetron? | Side Effects, Dosage, and More (Answered 2024)

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Can dogs take human ondansetronOndansetron is a prescription medication used to treat nausea and vomiting in humans.

While it can be effective in dogs, it is important to use the correct dosage and to be aware of potential side effects.

Key Takeaways

  • Ondansetron is an antiemetic used to treat severe nausea and vomiting in dogs.
  • The usual dose rate is between 0.05 and 0.5 mg per pound of the dog’s body weight given twice a day.
  • Side effects of ondansetron include constipation, drowsiness, and head shaking.
  • The risk factors for ondansetron include allergies, gastrointestinal blockage, abnormal heart rhythms, liver disease, pregnancy, and lactation.

What is Ondansetron?

What is Ondansetron
Ondansetron is an antiemetic used to treat severe nausea and vomiting in dogs and cats.

It’s given by mouth in the form of a tablet or liquid, and it may be given with or without food.

This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow.

How Does Ondansetron Work?

How Does Ondansetron Work
Ondansetron is an antiemetic that works by blocking serotonin receptors in the brain.

Here’s how it works in more detail:

  1. Ondansetron blocks serotonin receptors in the chemoreceptor trigger zone (CTZ) in the brain.
  2. This prevents serotonin from binding to these receptors and triggering nausea and vomiting.
  3. Ondansetron also reduces stomach acid and motility, which can help to relieve nausea and vomiting.

How is Ondansetron Given?

How is Ondansetron Given
Ondansetron is given by mouth in the form of a tablet or liquid, and it may be given with or without food.

Here are the steps on how to give your dog ondansetron:

  1. Wash your hands with soap and water.
  2. Open the bottle of ondansetron and read the label carefully.
  3. Measure the correct dose of ondansetron according to your veterinarian’s instructions.
  4. Give your dog the ondansetron with or without food.
  5. Rinse the measuring spoon or dropper with warm water after each use.

What Are the Side Effects of Ondansetron?

What Are the Side Effects of Ondansetron
Side effects of ondansetron in dogs are uncommon, but may include:

  • Constipation
  • Sleepiness
  • Head shaking

Rare side effects may include:

  • Arrhythmias
  • Sedation
  • Hypotension

What Are the Risk Factors for Ondansetron?

What Are the Risk Factors for Ondansetron
Ondansetron shouldn’t be used in pets that are allergic to it.

It should be used cautiously in pets with:

  • Gastrointestinal blockage
  • Certain abnormal heart rhythms
  • liver disease

    Some breeds of dogs (e.g., collies, sheepdogs, and collie- or sheepdog-cross breeds) are more sensitive than others to medications.

Risk Factors for Ondansetron**

In addition to side effects, there are also certain risk factors to consider when using ondansetron in dogs.

These include:

  • Allergies
  • Gastrointestinal blockage
  • Abnormal heart rhythms
  • Liver disease
  • Pregnancy or lactation

– Allergies

Ondansetron shouldn’t be used in pets that are allergic to it.

Allergic reactions to ondansetron can include:

  • Hives
  • Skin rash
  • Itching
  • Sneezing
  • Runny nose
  • Watery eyes

In severe cases, anaphylaxis (swelling of the throat and difficulty breathing) can occur.

– Gastrointestinal blockage

In addition to allergies, ondansetron should be used cautiously in pets with gastrointestinal blockage.

This is because the medication can worsen the blockage and cause further complications.

If your pet is experiencing gastrointestinal blockage, it’s important to seek veterinary attention immediately.

– Abnormal heart rhythms

Abnormal heart rhythms are a risk factor for ondansetron. Your veterinarian will need to take this into consideration before prescribing it to your pet.

Risk Factor Possible Side Effects
Abnormal heart rhythms Arrhythmias
Liver disease Hypotension
Pregnancy or lactation Not fully established

– Liver disease

Liver disease is another risk factor for ondansetron, as it can increase the risk of side effects such as:

  • Constipation
  • Diarrhea
  • Head shaking
  • Abnormal heart rhythms

What Are the Drug Interactions of Ondansetron?

What Are the Drug Interactions of Ondansetron
The following medications should be used with caution when given with ondansetron:

  • Apomorphine
  • Cisplatin
  • Cyclophosphamide
  • Certain heart medications
  • Serotonergic drugs
  • Tramadol

These medications can interact with ondansetron and increase your risk of serotonin syndrome, serotonin toxicity, or decreased efficacy of ondansetron.

If you’re taking any of these medications, talk to your veterinarian about whether or not you should take ondansetron.

How is Ondansetron Stored?

How is Ondansetron Stored
You should store ondansetron according to the manufacturer’s product instructions at controlled temperatures between 36-86 F.

  • The injection version of ondansetron should be stored between 36-77 F.
  • Keep the container tightly closed in order to protect from moisture and light.
  • Compounded medications should be stored according to the compounding pharmacy’s label.
  • Keep out of reach of children and pets.

What Should I Do in Case of an Overdose?

What Should I Do in Case of an Overdose
In case of an overdose, contact your veterinarian immediately. They may recommend:

  • Inducing vomiting
  • Administering activated charcoal
  • Monitoring your pet’s breathing
If your pet’s condition worsens or doesn’t improve, you should seek medical attention immediately.

Symptom

What to Do
Vomiting Induce vomiting with hydrogen peroxide or ipecac syrup.
Diarrhea Administer activated charcoal to bind the chemical and prevent absorption.
Low blood pressure Monitor your pet’s breathing and heart rate. If they become weak or lethargic, seek medical attention immediately.
Other symptoms If your pet is exhibiting any other symptoms, such as seizures, tremors, or difficulty breathing, seek medical attention immediately.

What Are the ‘just in Case’ Medications?

What Are the ‘just in Case’ Medications

In case of an overdose, you should give your pet activated charcoal followed by Pedialyte/Gatorade/Chicken Broth.

Just in Case Medications

  1. Pepto-Bismol
  2. Diet control
  3. Activated charcoal
  4. Call your vet

What is the Dosage of Ondansetron?

What is the Dosage of Ondansetron
The usual dose rate is between 0.05 and 0.5 mg per pound of dog’s bodyweight given twice a day.

Weight (lbs) Dose (mg)
10 0.5
20 1
30 1.5
40 2
50 2.5
60 3

Note: Ondansetron shouldn’t be used in pregnant or lactating dogs as safety hasn’t been clearly established.

Frequently Asked Questions (FAQs)

How long does ondansetron stay in a dog’s system?

Ondansetron stays in your dog’s system for about 24 hours.

It’s usually well tolerated by pets and can be given with or without food.

Ask your veterinarian if ondansetron is right treatment for your pet.

Can ondansetron cause diarrhea in dogs?

Yes, ondansetron can cause diarrhea in dogs.

It’s a common side effect of the medication and usually goes away on its own.

If the diarrhea is severe or persistent, talk to your veterinarian about other treatment options.

Is ondansetron safe for pregnant dogs?

Ondansetron is safe for pregnant dogs, but it should only be used if prescribed by your veterinarian.

Can ondansetron be used to treat motion sickness in dogs?

Yes, ondansetron can be used to treat motion sickness in dogs.

The usual dose is 05 to 5 mg per pound of body weight, given twice a day.

What are the alternative treatments for vomiting in dogs?

If your dog is vomiting, there are a number of alternative treatments available, including:

  • Pepto-Bismol
  • Diet control
  • Activated charcoal

Talk to your vet about which treatment is right for your pet.

Conclusion

While ondansetron can be effective in dogs, it’s important to use the correct dosage and to be aware of potential side effects.

Talk to your veterinarian about whether or not ondansetron is right for your dog.

References
  • midogguide.com
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Mutasim Sweileh

Mutasim is an author and software engineer from the United States, I and a group of experts made this blog with the aim of answering all the unanswered questions to help as many people as possible.